The details of FoldDB ID: fd0659 |
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| Identification | |
|---|---|
| FoldDB ID | fd0659 |
| One Letter code
Since there is no uniform representation for the non-natural peptides. The one letter code reported here is as it is mentioned in the original article and/or the external database. | Ac-EEQβWARβEIGAβQLRβRMADβDLNβAQYEβRR-NH2 |
| Other note | βX=Beta amino acid |
| Length | 26 |
| Source | synthetic construct |
| Other information | |
|---|---|
| Application | PUMA BH3 mimitic/anti cancer |
| Foldamer type | α/β Peptide |
| Structure Type | helical |
| Activity |
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| Activity ID | Assay name | Cell line | Target Protein | Organism | Assay Category | Value | Unit | Type | Measurement object |
|---|---|---|---|---|---|---|---|---|---|
| fdact0153 | Binding affinity | Bcl‐2 | In Vitro (Efficacy) | 7 | nM | IC50 | |||
| fdact0158 | Binding affinity | Bcl-w | In Vitro (Efficacy) | 42 | nM | IC50 | |||
| fdact0163 | Binding affinity | Bcl-xL | In Vitro (Efficacy) | 18 | nM | IC50 | |||
| fdact0168 | Binding affinity | Mcl-2 | In Vitro (Efficacy) | 480 | nM | IC50 | |||
| fdact0173 | Binding affinity | Mcl-1mut | In Vitro (Efficacy) | 140 | nM | IC50 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Structural Basis of Bcl-xL Recognition by a BH3-Mimetic α/β-Peptide Generated by Sequence-Based Design | 2011 | Lee, Erinna F., Smith, Brian J., Horne, W. Seth., Mayer, Kelsey N., Evangelista, Marco., Colman, Peter M., Gellman, Samuel H., Fairlie, W. Douglas | ChemBioChem | ||
