The details of FoldDB ID: fd0661 |
|---|
Use the buttons at the bottom of Jsmol viewer to see different representations, ON/OFF Hydrogens, and ON/OFF rotation.
3D model is for representation purpose only. To access the experimental 3D structure kindly go to the browse structure tab and look for PDB or CCDC id.
.
.
| Identification | |
|---|---|
| FoldDB ID | fd0661 |
| One Letter code
Since there is no uniform representation for the non-natural peptides. The one letter code reported here is as it is mentioned in the original article and/or the external database. | Ac-βWARβEIGAβQLRβRMADβDLNβAQYE-NH2 |
| Three Letter code
Since there is no uniform representation for the non-natural peptides. The three letter code reported here is as it is mentioned in the original article and/or the external database. | ACE HT7 ALA ARG B3E ILE GLY ALA B3Q LEU ARG HR7 MET ALA ASP B3D LEU ASN B3A GLN TYR GLU |
| Other note | βX=Beta amino acid |
| Length | 21 |
| Source | synthetic construct |
| External ID | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| NCBI Accession | |||||||||
| Other information | |
|---|---|
| Application | PUMA BH3 mimitic/anti cancer |
| Foldamer type | α/β Peptide |
| Structure Type | helical |
| Activity |
|---|
| Activity ID | Assay name | Cell line | Target Protein | Organism | Assay Category | Value | Unit | Type | Measurement object |
|---|---|---|---|---|---|---|---|---|---|
| fdact0155 | Binding affinity | Bcl‐2 | In Vitro (Efficacy) | 50.4 | nM | IC50 | |||
| fdact0160 | Binding affinity | Bcl-w | In Vitro (Efficacy) | 190 | nM | IC50 | |||
| fdact0165 | Binding affinity | Bcl-xL | In Vitro (Efficacy) | 26 | nM | IC50 | |||
| fdact0170 | Binding affinity | Mcl-4 | In Vitro (Efficacy) | 8000 | nM | IC50 | |||
| fdact0175 | Binding affinity | Mcl-1mut | In Vitro (Efficacy) | nd | nM | IC50 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Structural Basis of Bcl-xL Recognition by a BH3-Mimetic α/β-Peptide Generated by Sequence-Based Design | 2011 | Lee, Erinna F., Smith, Brian J., Horne, W. Seth., Mayer, Kelsey N., Evangelista, Marco., Colman, Peter M., Gellman, Samuel H., Fairlie, W. Douglas | ChemBioChem | ||
