The details of FoldDB ID: fd0955 |
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| Identification | |
|---|---|
| FoldDB ID | fd0955 |
| Other Name
Since there is no uniform representation for the non-natural peptides. This is the name as it is mentioned in the original article and/or the external database. | Ac-NH-(3R)-pyrrolidine-(4S)-CO-Leu-NH-cyclopentane-(2S)-CO-Leu-NH-pyrrolidine-(3R)-CO-Leu-[NH-(1S)-cyclopentane-(2S)-CO-Lys-NH-(1S)-cyclopentane-(2S)-CO-Leu]2-NH-(3R)-pyrrolidine-(2S)-CONH2 |
| Source | synthetic construct |
| External ID | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Reaxys ID | 9756049 | ||||||||
| Structural Information | |
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| Structure reported | Yes |
| Method | NMR, X-Ray |
| Other information | |
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| Application | antimicrobial activity |
| Foldamer type | α/β Peptide |
| Structure Type | helical |
| Activity |
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| Activity ID | Assay name | Cell line | Target Protein | Organism | Assay Category | Value | Unit | Type | Measurement object |
|---|---|---|---|---|---|---|---|---|---|
| fdact0544 | Escherichia coli JM109 | In Vitro (Efficacy) | > 100 | μg/mL | MIC | ||||
| fdact0545 | B. subtilis | In Vitro (Efficacy) | 6.3 | μg/mL | MIC | ||||
| fdact0546 | E. faecium | In Vitro (Efficacy) | 25 | μg/mL | MIC | ||||
| fdact0547 | S. aureus | In Vitro (Efficacy) | 50 | μg/mL | MIC | ||||
| fdact0548 | erythrocyte | human | Hemolytic Activities | max. conc. without hemolysis: 1.6 | μg/mL | qualitative |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Unexpected Relationships between Structure and Function in α,β-Peptides:  Antimicrobial Foldamers with Heterogeneous Backbones | 2004 | Schmitt, Margaret A., Weisblum, Bernard., Gellman, Samuel H. | Journal of the American Chemical Society | ||
Role of membrane lipids in the mechanism of bacterial species selective toxicity by two α/β-antimicrobial peptides | 2006 | Epand, Raquel F., Schmitt, Margaret A., Gellman, Samuel H., Epand, Richard M. | Biochimica et Biophysica Acta (BBA) – Biomembranes | ||
Bacterial species selective toxicity of two isomeric α/β-peptides: Role of membrane lipids | 2005 | Epand, Raquel F., Schmitt, Margaret A., Gellman, Samuel H., Sen, Arindam., Auger, Michèle., Hughes, Donald W., Epand, Richard M. | Molecular Membrane Biology | ||
