The details of FoldDB ID: fd1088 |
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| Identification | |
|---|---|
| FoldDB ID | fd1088 |
| Smiles | |
| Inchi Key | FODCUJJUVOMHIU-IRFCIJBXSA-N |
| Molecular weight | 545.636 |
| Molecular formula | C27H39N5O7 |
| Source | synthetic construct |
| External ID | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Reaxys ID | 9827975 | ||||||||
| Structural Information | |
|---|---|
| Structure reported | yes |
| Method | NMR |
| NMR Solvent | CD3OH |
| Other information | |
|---|---|
| Application | p53-hDM2 Interaction’s inhibitors |
| Foldamer type | β Peptide |
| Other type | β3-Peptides |
| Calculated properties | |
|---|---|
| LogP | 0.02700 |
| H Bond Donor | 7 |
| H Bond Acceptor | 12 |
| Polar Surface Area (PSA) | 203.71000 |
| Activity |
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| Activity ID | Assay name | Cell line | Target Protein | Organism | Assay Category | Value | Unit | Type | Measurement object |
|---|---|---|---|---|---|---|---|---|---|
| fdact0715 | Protein binding Bioassay | In Vitro (Efficacy) | 1 | µM | IC50 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Helical β-Peptide Inhibitors of the p53-hDM2 Interaction | 2004 | Kritzer, Joshua A., Lear, James D., Hodsdon, Michael E., Schepartz, Alanna | Journal of the American Chemical Society | ||
