The details of FoldDB ID: fd1063 |
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| Identification | |
|---|---|
| FoldDB ID | fd1063 |
| One Letter code
Since there is no uniform representation for the non-natural peptides. The one letter code reported here is as it is mentioned in the original article and/or the external database. | GPSQPTYPGDDAPVVDLIRFRGRWLAYLGDTINRY |
| Source | Phage display |
| External ID | |
|---|---|
| Reaxys ID | 9992897 |
| Other information | |
|---|---|
| Application | BCL-2 binder |
| Foldamer type | α Peptide |
| Activity |
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| Activity ID | Assay name | Cell line | Target Protein | Organism | Assay Category | Value | Unit | Type | Measurement object |
|---|---|---|---|---|---|---|---|---|---|
| fdact0695 | protein bindingBcl-2 | Apoptosis regulator, Bcl-2 | In Vitro (Efficacy) | 742 | nM | IC50 | |||
| fdact0696 | protein bindingglutathione-s-transferase | Glutathione S-transferase | In Vitro (Efficacy) | > 30 | µM | Kd (dissociation constant) | |||
| fdact0697 | protein bindingcalmodulin | Calmodulin | In Vitro (Efficacy) | > 1 | mM | Kd (dissociation constant) | |||
| fdact0698 | protein bindingBcl-2 protein | In Vitro (Efficacy) | 0.5 | µM | Kd (dissociation constant) | ||||
| fdact0699 | protein bindingBcl-XL protein | In Vitro (Efficacy) | 2.7 | µM | Kd (dissociation constant) | ||||
| fdact0700 | protein bindingBcl-XL protein, A104D mutant | In Vitro (Efficacy) | 0.77 | µM | Kd (dissociation constant) | ||||
| fdact0701 | protein bindingBcl-XL protein, L108M mutant | In Vitro (Efficacy) | 9.3 | µM | Kd (dissociation constant) | ||||
| fdact0702 | protein bindingBcl-XL protein, S122R mutant | In Vitro (Efficacy) | 0.39 | µM | Kd (dissociation constant) | ||||
| fdact0703 | protein bindingbovine serum albumin | In Vitro (Efficacy) | > 30 | µM | Kd (dissociation constant) |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Paralog-Selective Ligands for Bcl-2 Proteins | 2005 | Gemperli, Anja C., Rutledge, Stacey E., Maranda, Abby., Schepartz, Alanna | Journal of the American Chemical Society | ||
