The details of FoldDB ID: fd1151 |
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| Identification | |
|---|---|
| FoldDB ID | fd1151 |
| Smiles | |
| Inchi Key | RLVUXGADSMRLJX-QZEGOLKGSA-N |
| Molecular weight | 1378.89 |
| Molecular formula | C68H131N17O12 |
| Other Name
Since there is no uniform representation for the non-natural peptides. This is the name as it is mentioned in the original article and/or the external database. | H-(beta3-HAla-beta3-HLys-beta3-HVal)4-NH2 |
| Source | synthetic construct |
| External ID | |
|---|---|
| Reaxys ID | 9038884 |
| Other information | |
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| Application | Antimicrobial |
| Foldamer type | β Peptide |
| Other type | β3peptide |
| Calculated properties | |
|---|---|
| LogP | -1.48400 |
| H Bond Donor | 17 |
| H Bond Acceptor | 29 |
| Polar Surface Area (PSA) | 493.29000 |
| Activity |
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| Activity ID | Assay name | Cell line | Target Protein | Organism | Assay Category | Value | Unit | Type | Measurement object |
|---|---|---|---|---|---|---|---|---|---|
| fdact0799 | Cell/tumor cell: proliferation/viability/growth | Toxicity/Safety Pharmacology | 5 | mM | IC50 | ||||
| fdact0800 | Cell/tumor cell: proliferation/viability/growth | Toxicity/Safety Pharmacology | 26 | mg/L | MIC | ||||
| fdact0801 | erythrocyte | human | In Vitro (Efficacy) | 910 | µM | EC50 | HC50 | ||
| fdact0805 | Binding activity | 1.4 | µM | Kd (dissociation constant) |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
De Novo Design, Synthesis, and Characterization of Antimicrobial β-Peptides | 2001 | Liu, Dahui., DeGrado, William F., | Journal of the American Chemical Society | ||
